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. 2019 Dec 27;21(1):201. doi: 10.3390/ijms21010201

Figure 3.

Figure 3

Effects of cardiosomes on fibroblast activation. Fibroblasts were incubated with cardiosomes obtained from cardiomyocytes isolated from SHAM and MI mice (n ≥ 6 mice/group) seven days post-surgery; such incubation induced an upregulation of miR-195 (A), αSMA (B), collagen I and III (C) fibroblast activation protein (FAP, D), periostin (E), fibronectin containing extra domain A (Fibronectin ED-A, F), chemokine (C-X-C motif) ligand 1 (CXCL1, G), interleukin-6 (IL-6, H). Mean ± S.E.M. of at least three independent experiments; * p < 0.05 vs. SHAM.