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Effects of conditioned cardiomyocyte medium on the activation of fibroblasts. Conditioned medium from cardiomyocytes isolated (n ≥ 6 mice/group) seven days post-MI induced an upregulation of miR-195, αSMA, and periostin. However, the addition of an inhibitor of cardiosome release (GW4869 10 μM for 12 h) significantly attenuated these responses. Mean ± S.E.M. of at least three independent experiments; * p < 0.05 vs. SHAM.
