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. 2019 Dec 28;21(1):220. doi: 10.3390/ijms21010220

Figure 4.

Figure 4

α-TCT protects mitochondrial function against glutamate challenge. Primary hippocampal neurons were treated with α-TCT (1 µM), glutamate (20 µM), or a combination of both. tetramethylrhodamine (TMRM)-stained neurons were imaged (A), and TMRM fluorescent intensity was quantified (B) at 6 h after treatment (n = 23–25 cells per group). (C) ATP levels (n = 24 wells per group) at 8 h after treatment. (D) Primary hippocampal neurons were treated with Ac-DEVD-CHO (10 μM), glutamate (20 µM), or a combination of both. TMRM fluorescent intensity was quantified (n = 20 cells per group). Scale bar = 10 µm. * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001, one-way ANOVA.