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. 2019 Dec 23;21(1):117. doi: 10.3390/ijms21010117

Figure 9.

Figure 9

Inhibitory effect of HBA on IK(M) density in hippocampal mHippoE-14 neurons. In this set of recordings, experimental conditions similar to those for the studies in GH3 cells described above were applied. (A) Superimposed traces of IK(M) density elicited by membrane depolarization from −50 to −10 mV (indicated in the upper part). (a) control; (b) 3 µM HBA; (c) 10 µM HBA. In (B) and (C), the summary bar graphs show the effects of HBA on the density and τact of IK(M), respectively (mean ± SEM; n = 9 for each bar). (a) control; (b) 3 µM HBA; (c) 10 µM HBA. *p < 0.05 vs. the controls. Note that, indistinguishable from the experimental results taken from GH3 cells as described above, the presence of HBA exerts an inhibitory effect on IK(M) density along with a conceivable slowing in the activation time course of the current density in these neurons.