Scheme A1.
Reagents and conditions: (a) ethylpyruvate, AcOH, EtOH, rf, 2 h, 95%; (b) PPA, 110 °C, 5 h, 60%; (c) DMF, K2CO3, 0 °C, 30 min, 70%; (d) NaOH (2N), rf, 3 h, 60%.
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