Table 4.

Associations between placental LEP DNA methylation levels and maternal glycemia during pregnancy.

CpG Sites	Maternal Glucose 1 h Post 50 g GCT at 1st Trimester of Pregnancy	Maternal Fasting Glucose at 2nd Trimester of Pregnancy	Maternal Glucose 2 h Post 75 g OGTT at 2nd Trimester of Pregnancy
cg15758240	β < 0.001 p = 0.74	β = −0.013 p = 0.04	β < 0.001 p = 0.21
cg05136031	β < 0.001 p = 0.72	Β < 0.001 p = 0.55	Β < 0.001 p = 0.94

Significant results when p ≤ 0.05. Models were adjusted for maternal age and BMI at 1st trimester of pregnancy, gestational age at delivery, sex of the child, age at follow-up, and placenta heterogeneity.