Table 2.
The top 10 significantly enriched biological processes upregulated in MI patients (from gene ontology (GO) analysis of the 276 predicted miRNA target genes). The GO list revealed relationships with muscle tissue development, striated muscle tissue development, type I pneumocyte differentiation, muscle structure development, skeletal muscle organ development, heart development, regulation of muscle tissue development, regulation of striated muscle tissue development, regulation of muscle organ development, and regulation of skeletal muscle cell differentiation.
| GOID | GO Term | Term p-value | Term p-value Corrected with Benjamini-Hochberg | % Associated | Associated mRNA |
|---|---|---|---|---|---|
| GO:0060537 | muscle tissue development | 0.000000 | 0.000021 | 5.56 | ACADM, AKAP6, ARID2, COL11A1, CREB1, DDX5, FOXP1, HNRNPU, HOMER1, IGF1, ITGB1, LEMD2, MEF2D, MYOCD, NLN, NR1D2, PDGFRA, PKD2, PRKAA1, RBFOX1, RPS6KB1, SKIL] |
| GO:0060537 | muscle tissue development | 0.000000 | 0.000021 | 5.56 | [ACADM, AKAP6, ARID2, COL11A1, CREB1, DDX5, FOXP1, HNRNPU, HOMER1, IGF1, ITGB1, LEMD2, MEF2D, MYOCD, NLN, NR1D2, PDGFRA, PKD2, PRKAA1, RBFOX1, RPS6KB1, SKIL] |
| GO:0014706 | striated muscle tissue development | 0.000000 | 0.000022 | 5.56 | [ACADM, AKAP6, ARID2, COL11A1, CREB1, DDX5, FOXP1, HNRNPU, HOMER1, IGF1, ITGB1, LEMD2, MEF2D, MYOCD, NLN, NR1D2, PDGFRA, PRKAA1, RBFOX1, RPS6KB1, SKIL] |
| GO:0014706 | striated muscle tissue development | 0.000000 | 0.000022 | 5.56 | [ACADM, AKAP6, ARID2, COL11A1, CREB1, DDX5, FOXP1, HNRNPU, HOMER1, IGF1, ITGB1, LEMD2, MEF2D, MYOCD, NLN, NR1D2, PDGFRA, PRKAA1, RBFOX1, RPS6KB1, SKIL |
| GO:0060509 | type I pneumocyte differentiation | 0.000000 | 0.000025 | 80.00 | CREB1, NFIB, THRA, THRB |
| GO:0061061 | muscle structure development | 0.000002 | 0.000156 | 4.05 | ACADM, AKAP6, ANKRD17, BASP1, COL11A1, CREB1, DDX5, EREG, ETV1, FOXP1, HNRNPU, HOMER1, IGF1, ITGB1, LEMD2, MBNL1, MEF2D, MYOCD, NLN, NR1D2, PDGFRA, PRKAA1, RBFOX1, RPS6KB1, SKIL, THRA |
| GO:0061061 | muscle structure development | 0.000002 | 0.000156 | 4.05 | ACADM, AKAP6, ANKRD17, BASP1, COL11A1, CREB1, DDX5, EREG, ETV1, FOXP1, HNRNPU, HOMER1, IGF1, ITGB1, LEMD2, MBNL1, MEF2D, MYOCD, NLN, NR1D2, PDGFRA, PRKAA1, RBFOX1, RPS6KB1, SKIL, THRA |
| GO:0060538 | skeletal muscle organ development | 0.000002 | 0.000158 | 7.14 | BASP1, DDX5, FOXP1, HOMER1, LEMD2, MEF2D, MYOCD, NLN, NR1D2, PRKAA1, RBFOX1, RPS6KB1, SKIL |
| GO:0016202 | regulation of striated muscle tissue development | 0.000003 | 0.000170 | 8.40 | AKAP6, CREB1, DDX5, FOXP1, IGF1, MYOCD, NLN, NR1D2, PRKAA1, RBFOX1, RPS6KB1 |
| GO:1901861 | regulation of muscle tissue development | 0.000003 | 0.000169 | 8.27 | AKAP6, CREB1, DDX5, FOXP1, IGF1, MYOCD, NLN, NR1D2, PRKAA1, RBFOX1, RPS6KB1 |