Table 3.
miRNA-targeted VSMC-related genes (based on novel 21-gene classifiers). The seven genes were negatively regulated in the group of MI patients.
| miRNA | Target Gene Symbol | Description | Biological Processes |
|---|---|---|---|
|
hsa-miR-1,
hsa-let-7b-5p |
FOXP1 | forkhead box P1 | heart development |
| hsa-miR-1 | MYOCD | myocardin | regulation of smooth muscle contraction |
| hsa-miR-20b-5p | PKD2 | polycystic kidney disease 2 | heart development |
| hsa-miR-30b-5p | MBNL1 | muscleblind-like | striated muscle tissue development |
| hsa-miR-20b-5p | ATP1A2 | ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide | regulation of smooth muscle contraction |
|
hsa-miR-20b-5p,
hsa-miR-26a-5p |
EREG | epiregulin | regulation of muscle cell differentiation |
| hsa-miR-1226-3p | ITGB1 | integrin, beta 1 | heart development |