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. Author manuscript; available in PMC: 2020 Aug 21.
Published in final edited form as: ACS Chem Neurosci. 2019 Aug 5;10(8):3769–3777. doi: 10.1021/acschemneuro.9b00281

Figure 1. Representative examples of different kinetic mechanisms of HDAC inhibition.

Figure 1.

Assay progression curves and secondary plots fitted to the relevant equation (see Supporting Information for more detail). (A) Fast-on/fast-off binding kinetics, exemplified by apicidin (6a), (B) mechanism A of slow-binding kinetics, exemplified by trapoxin A (4), and (C) mechanism B of slow-binding inhibition, exemplified by tacedinaline (3).