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. 2019 Dec 24;21(1):127. doi: 10.3390/ijms21010127

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Influence of ∆p53α isoforms with inducible expression on transactivation activity of constitutively expressed FLp53α. (A) in media with 0.2 % galactose; (B) in media with 2% galactose. Four isogenic yeast strains were used, with the p53 target site (PUMA), with the p53 target site after G4 forming sequence (G4-PUMA), with the p53 target site before G-quadruplex forming sequence (PUMA-G4), and the G4 forming sequence upstream of the luciferase gene. Asterisks indicate a significant induction of p53-dependent transactivation (p < 0.05).

Influence of ∆p53α isoforms with inducible expression on transactivation activity of constitutively expressed FLp53α. (A) in media with 0.2 % galactose; (B) in media with 2% galactose. Four isogenic yeast strains were used, with the p53 target site (PUMA), with the p53 target site after G4 forming sequence (G4-PUMA), with the p53 target site before G-quadruplex forming sequence (PUMA-G4), and the G4 forming sequence upstream of the luciferase gene. Asterisks indicate a significant induction of p53-dependent transactivation (p < 0.05).