Figure 8.

Schematic model of p53 isoforms binding to a RE associated with G4 sequence. (A) FLp53α or ∆40p53α bind effectively to the RE and there is a high or moderate level of transactivation. (B) ∆133p53α and ∆160p53α inhibit FLp53α transactivation, (C) the presence of a G4 close to the RE decreases accessibility of the TA domains and FLp53α transactivation, (D) which is not more inhibited by ∆133p53α and ∆160p53α, although steric protein orientation is impaired due to the G4 structure. TA is the blue domain, rest of the protein is in green, column represent transactivation induced by p53 complex (red column FLp53α, blue FLp53α with ∆133p53α and ∆160p53α isoforms).