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. 2020 Jan 2;21(1):311. doi: 10.3390/ijms21010311

Figure 1.

Figure 1

Pedigree, segregation of the CDC14A variants in families 1 and 2 and pure-tone audiometry. (a,b) An Iranian ((a) family 1) and Pakistani family ((b) family 2) with a consanguineous background, each showing two affected individuals ((a), II.2, II.8; (b) II.1, II.2) who are shown in black symbols. Unaffected parents and siblings are shown in white symbols. The probands are marked with arrows. The mutated allele is marked with a “-”. The wild type allele is displayed with a “+”. Sanger sequence chromatograms of the CDC14A c.1421+2T>C variant in wild type (WT; (a), left) and homozygous ((a), right) orientation and the CDC14A c.1041dup variant in heterozygous ((b), left) and homozygous ((b), right) orientation. (c,d) Audiograms showing pure-tone air conduction thresholds of II.2 ((c), family 1) and II.1, II.2 ((d), family 2). Air conduction thresholds for right and left ears are represented with circles and crosses, respectively. Abbreviations: het, heterozygous; hom, homozygous; wt, wild type.