Table 2: 23-miRNA expression signature predicted using 18 different feature extraction algorithms.
Column 1 lists the names of miRNAs and column 2 shows the total number of feature selection algorithms in which the corresponding miRNA was predicted as part of the classifier. Column 3 lists the physiological functions and disease correlation of the individual miRNAs identified from miRbase 52–56 and MGI57 (and references therein). PubMed search was also used for identifying functional characterization of some of the miRNAs.
| 23-miRNA classifier | # F-S methods | Physiological Function |
|---|---|---|
| mmu-miR-223–3p | 15 | Hematopoietic |
| mmu-miR-21a-5p | 12 | Role in cell apoptosis, growth, and proliferation |
| mmu-miR-3096b-3p | 11 | Limited data on function, all NGS predicted |
| mmu-miR-5115 | 11 | Fragment of LSU rRNA. Limited data on function, all NGS predicted |
| mmu-miR-150–5p | 9 | Hematopoietic |
| mmu-miR-20b-5p | 9 | Hematopoietic |
| mmu-miR-20a-5p | 8 | Hematopoietic |
| mmu-miR-24–3p | 8 | Hematopoietic |
| mmu-miR-574–5p | 8 | Hematopoietic |
| mmu-miR-222–3p | 8 | Development in heart, skin. Melanoma marker |
| mmu-miR-140–5p | 7 | Tissue homeostasis |
| mmu-miR-1839–3p | 7 | Noncanonical miRNA |
| mmu-miR-29b-3p | 7 | Hematopoietic |
| mmu-miR-466i-5p | 7 | Immune response and inflammation |
| mmu-let-7f-5p | 6 | Hematopoietic response to Cytokines |
| mmu-miR-3082–5p | 6 | Role not clear, downregulation associated with melanoma |
| mmu-miR-30e-5p | 6 | Adipocyte and osteoblast differentiation |
| mmu-miR-98–5p | 6 | Tumor suppression and apoptosis. |
| mmu-miR-22–5p | 6 | Probably Hematopoietic |
| mmu-let-7b-5p | 6 | Hematopoietic response to Cytokines |
| mmu-miR-30d-5p | 6 | Invasion and immunosuppression, autophagy |
| mmu-miR-320–3p | 6 | Hematopoietic |
| mmu-miR-30c-5p | 6 | Hematopoietic |