Table 5: Negative Correlation in the expression levels of miR-17 sisters and the gene targets from miRTarBase.

Pairwise pearson’s correlation was performed for the common time-points (24 h and 48 h) and doses (2, 4 and 8 Gy) between miRNA and mRNA expression data. The correlation coefficients and associated correlation p-values are shown for the selected targets

	mmu-miR-17–5p		mmu-miR-20a-5p		mmu-miR-20b-5p		mmu-miR-106b-5p
	CoR_Coeff	P-value	CoR_Coeff	P-value	CoR_Coeff	P-value	CoR_Coeff	P-value
Ulk1	−0.99	0.000	−0.96	0.001	−0.94	0.002	−0.93	0.002
Atg7	−0.99	0.000	−1.00	0.000	−0.99	0.000	−0.93	0.002
Trim8	−0.99	0.000	−0.97	0.000	−0.96	0.001	−0.96	0.001
Mapk14	−0.98	0.000	−0.98	0.000	−0.96	0.000	−0.95	0.001
Egln3	−0.98	0.000	−0.98	0.000	−0.97	0.000	−0.95	0.001
Mfn2	−0.96	0.000	−0.90	0.005	−0.88	0.009	−0.87	0.010
Mdm2	−0.96	0.001	−0.90	0.006	−0.90	0.006	−0.77	0.045
Trp53inp1	−0.95	0.001	−0.87	0.011	−0.86	0.014	−0.79	0.033
Pdlim7	−0.95	0.001	−0.98	0.000	−0.97	0.000	−0.96	0.001
Limk1	−0.95	0.001	−0.92	0.003	−0.92	0.004	−0.84	0.017
Rhoc	−0.94	0.002	−0.95	0.001	−0.96	0.001	−0.85	0.016
Epas1	−0.93	0.002	−0.94	0.002	−0.93	0.002	−0.90	0.005
Fyn	−0.93	0.003	−0.91	0.005	−0.88	0.008	−0.93	0.002
Fas	−0.93	0.003	−0.89	0.008	−0.88	0.009	−0.83	0.022
Akt3	−0.93	0.003	−0.94	0.002	−0.92	0.003	−0.98	0.000
Tnfsf12	−0.92	0.003	−0.88	0.010	−0.87	0.010	−0.72	0.066
Rhoc	−0.92	0.003	−0.93	0.002	−0.94	0.001	−0.82	0.025
Gpr137b	−0.92	0.003	−0.85	0.015	−0.84	0.017	−0.76	0.049
Dnmt3a	−0.92	0.003	−0.85	0.016	−0.82	0.023	−0.83	0.020
Tbc1d2	−0.91	0.004	−0.94	0.002	−0.92	0.003	−0.99	0.000
Mfn2	−0.90	0.006	−0.86	0.014	−0.83	0.022	−0.90	0.006
Map2k3	−0.90	0.006	−0.90	0.006	−0.88	0.009	−0.92	0.003
Timp2	−0.89	0.007	−0.89	0.007	−0.91	0.005	−0.75	0.052
Klf9	−0.89	0.008	−0.87	0.010	−0.87	0.011	−0.74	0.056
Pura	−0.88	0.009	−0.84	0.018	−0.81	0.026	−0.82	0.023
Pdlim7	−0.88	0.010	−0.93	0.002	−0.92	0.003	−0.94	0.002
Runx1	−0.87	0.011	−0.92	0.003	−0.91	0.004	−0.96	0.001
Timp2	−0.86	0.013	−0.82	0.023	−0.83	0.022	−0.71	0.074
Jak1	−0.86	0.013	−0.77	0.043	−0.74	0.058	−0.79	0.033
Bmp2	−0.85	0.014	−0.88	0.008	−0.89	0.008	−0.87	0.011
Timp3	−0.84	0.017	−0.85	0.015	−0.82	0.024	−0.83	0.020
Ccnd1	−0.84	0.019	−0.88	0.009	−0.90	0.006	−0.75	0.054
Slc2a3	−0.83	0.021	−0.90	0.005	−0.90	0.006	−0.93	0.002
Rad21	−0.79	0.033	−0.66	0.107	−0.63	0.130	−0.67	0.101
Stat3	−0.78	0.038	−0.68	0.095	−0.67	0.101	−0.58	0.172
Bnip2	−0.77	0.043	−0.65	0.112	−0.63	0.130	−0.62	0.141
Ephb4	0.75	0.050	0.63	0.131	0.61	0.145	0.57	0.182
Abl2	−0.72	0.069	−0.56	0.187	−0.54	0.210	−0.50	0.253
Cdkn1a	−0.71	0.072	−0.79	0.036	−0.82	0.024	−0.66	0.110
Hipk3	−0.66	0.106	−0.56	0.193	−0.52	0.236	−0.64	0.122
Clu	−0.66	0.107	−0.77	0.045	−0.77	0.045	−0.85	0.016