Table 3.
Log2 transformed label-free quantification (LFQ) intensity values of APPs determined by mass spectrometry in the kidneys of mice after LPS administration. Values are given as mean ± standard deviation (SD). *: p < 0.05, **: p ≤ 0.01, ***: p ≤ 0.001. EP (1.5 and 6 h) and LP (24 and 48 h) were statistically analysed separately (double line). Lcn-2: lipocalin-2, C3: complement C3, Fga: fibrinogen-α, Fgb: fibrinogen-β, Fgg: fibrinogen-γ, Saa: serum amyloid A, Cp: ceruloplasmin, Hp: haptoglobin, Hpx: hemopexin, Itih4: inter alpha-trypsin inhibitor heavy chain 4, FHC: ferritin heavy chain, Tf: transferrin, Alb: serum albumin, Serpina1: alpha-1-antitrypsin, Serpina3k: serine protease inhibitor A3K, Serpina3n: serine protease inhibitor A3N, A2m: alpha-2-macroglobulin, B2m: beta-2-microglobulin, ApoA1: apolipoprotein A1, ApoE: apolipoprotein E, A1AGP: α-1-acid glycoprotein, Itih1: inter alpha-trypsin inhibitor heavy chain 1, DBP: vitamin D-binding protein, Vwa5a: von Willebrand factor A domain-containing protein 5A.
| Saline | EP1.5 | EP6 | LP24 | LP48 | |
|---|---|---|---|---|---|
| Lcn-2 | 20.65 ± 1.10 | 20.31 ± 1.00 | 24.20 ± 0.23 *** | 27.01 ± 0.66 *** | 26.36 ± 0.77 *** |
| C3 | 21.94 ± 1.69 | 23.29 ± 1.23 | 21.24 ± 1.20 | 28.03 ± 0.41 *** | 27.51 ± 0.69 *** |
| Fga | 21.78 ± 1.61 | 23.20 ± 2.08 | 22.85 ± 1.77 | 27.63 ± 0.53 *** | 26.54 ± 0.67 *** |
| Fgb | 21.53 ± 1.56 | 21.84 ± 0.85 | 21.36 ± 0.55 | 27.15 ± 0.74 *** | 26.28 ± 0.88 *** |
| Fgg | 21.26 ± 1.89 | 22.06 ± 1.42 | 23.00 ± 1.58 | 26.93 ± 0.44 *** | 26.38 ± 0.55 *** |
| Saa1 | 20.84 ± 0.79 | 21.03 ± 0.79 | 21.01 ± 0.59 | 23.09 ± 0.57 ** | 23.84 ± 0.92 *** |
| Saa2 | 20.38 ± 0.50 | 19.77 ± 0.78 | 21.28 ± 0.34 | 24.30 ± 0.39 *** | 23.91 ± 1.09 *** |
| Cp | 21.34 ± 1.15 | 20.52 ± 0.68 | 19.85 ± 0.79 | 25.06 ± 0.29 *** | 24.41 ± 0.50 *** |
| Hp | 21.06 ± 0.62 | 20.53 ± 0.48 | 21.04 ± 1.10 | 26.31 ± 0.58 *** | 26.07 ± 0.76 *** |
| Hpx | 22.15 ± 0.84 | 20.66 ± 0.37 | 21.91 ± 1.03 | 28.05 ± 0.27 *** | 27.77 ± 0.67 *** |
| Itih4 | 20.77 ± 0.76 | 20.73 ± 0.92 | 21.14 ± 0.49 | 25.60 ± 0.51 *** | 23.96 ± 1.33 ** |
| FHC | 23.57 ± 0.72 | 24.65 ± 0.47 * | 24.99 ± 0.28 ** | 26.36 ± 0.32 *** | 26.26 ± 0.43 *** |
| Tf | 26.25 ± 1.26 | 27.36 ± 0.44 | 26.83 ± 0.46 | 28.51 ± 0.27 ** | 27.79 ± 0.47 * |
| Alb | 29.60 ± 0.85 | 31.06 ± 0.51 * | 29.97 ± 0.29 | 31.82 ± 0.20 *** | 30.47 ± 0.50 |
| Serpina1a,c | 23.84 ± 1.30 | 25.81 ± 0.70 * | 25.44 ± 0.37 | 26.84 ± 0.28 *** | 25.32 ± 0.34 * |
| Serpina3k | 22.88 ± 2.55 | 26.04 ± 0.79 | 25.22 ± 0.96 | 27.37 ± 0.52 ** | 26.32 ± 0.91 * |
| Serpina3n | 20.53 ± 0.75 | 20.83 ± 0.84 | 20.90 ± 0.47 | 23.27 ± 0.41 ** | 22.06 ± 1.18 |
| A2m | 22.13 ± 1.92 | 23.45 ± 2.12 | 21.00 ± 0.52 | 26.34 ± 0.52 ** | 25.16 ± 1.37 * |
| B2m | 20.80 ± 0.75 | 20.05 ± 0.49 | 21.82 ± 1.45 | 23.70 ± 0.24 *** | 24.25 ± 0.37 *** |
| ApoA1 | 25.16 ± 1.35 | 26.48 ± 0.67 | 25.26 ± 0.34 | 27.30 ± 0.68 * | 26.22 ± 0.35 |
| ApoE | 20.42 ± 1.10 | 21.58 ± 1.12 | 20.58 ± 0.95 | 22.70 ± 1.20 * | 21.46 ± 0.81 |
| A1AGP | 20.12 ± 0.96 | 20.25 ± 0.58 | 20.57 ± 0.56 | 21.12 ± 1.02 | 23.36 ± 0.55 *** |
| Itih1 | 20.10 ± 0.68 | 21.14 ± 0.50 | 21.08 ± 1.02 | 21.32 ± 0.36 * | 21.10 ± 0.69 |
| DBP | 20.54 ± 0.75 | 21.04 ± 0.45 | 20.46 ± 0.29 | 22.78 ± 0.50 *** | 21.33 ± 0.37 |
| Vwa5a | 20.75 ± 0.56 | 20.56 ± 0.58 | 20.44 ± 0.69 | 22.29 ± 1.57 | 23.08 ± 0.12 * |