AE(s) |
Adverse effect(s) |
AKT |
Protein kinase B |
ATC |
Anaplastic thyroid cancer |
c-KIT |
Stem cell factor receptor |
DTC |
Differentiated thyroid cancer |
EGFR |
Epidermal growth factor receptor |
ERK |
Mitogen-activated protein kinase |
FGFR |
Fibroblast growth factor receptor |
FLT-3 |
FMS-like tyrosine kinase 3 |
FTC |
Follicular thyroid cancer |
HCC |
Hürthle cell carcinoma |
HIF |
Hypoxia-inducible factor |
MEK |
Mitogen-activated protein kinase kinase |
MET |
Hepatocyte growth factor receptor |
MKI(s) |
Multikinase inhibitor(s) |
MTC |
Medullary thyroid cancer |
mTOR |
Mammalian target of rapamycin |
N/A |
Not available |
N/R |
Not reached |
OS |
Overall survival |
PDGFR |
Platelet-derived growth factor receptor |
PDTC(s) |
Poorly differentiated thyroid cancer(s) |
PFS |
Progression-free survival |
PGF |
Placental growth factor |
PI3K |
phosphoinositide 3-kinase |
PRISMA |
Preferred Reporting Items for Systematic Reviews and Meta-Analyses |
PTC |
Papillary thyroid cancer |
RAF |
Rapidly accelerated fibrosarcoma kinase |
RAI |
Radioactive iodine |
RAS |
Rat sarcoma protein |
RET |
Rearranged during transfection |
RECIST |
Response Evaluation Criteria in Solid Tumors |
RR |
Response rate |
TSH |
Thyroid-stimulating hormone |
VEGF |
Vascular endothelial growth factor |
VEGFR |
Vascular endothelial growth factor receptor |
VHL |
Von Hippel–Lindau tumor suppressor |