Table 2.
Genotype distributions of fibroblast growth factor receptor 4 (FGFR4) gene polymorphisms in 856 controls and 428 patients with UCC.
| Variable | Controls (N = 856) n (%) |
Patients (N = 428) n (%) |
OR (95% CIs) | AOR (95% CIs) |
|---|---|---|---|---|
| rs2011077 | ||||
| TT | 221 (25.8%) | 110 (25.7%) | 1.000 (reference) | 1.000 (reference) |
| TC | 418 (48.8%) | 224 (52.3%) | 1.077 (0.813–1.425) | 1.267 (0.863–1.860) |
| CC | 217 (25.4%) | 94 (22.0%) | 0.870 (0.624–1.214) | 0.781 (0.487–1.252) |
| TC + CC | 635 (74.2%) | 318 (74.3%) | 1.006 (0.772–1.312) | 1.095 (0.759–1.579) |
| rs351855 | ||||
| GG | 242 (28.3%) | 114 (26.6%) | 1.000 (reference) | 1.000 (reference) |
| GA | 426 (49.7%) | 222 (51.9%) | 1.106 (0.840–1.457) | 1.406 (0.963–2.055) |
| AA | 188 (22.0%) | 92 (21.5%) | 1.039 (0.744–1.451) | 0.982 (0.609–1.582) |
| GA + AA | 614 (71.7%) | 314 (73.4%) | 1.086 (0.836–1.409) | 1.274 (0.886–1.831) |
| rs7708357 | ||||
| GG | 838 (97.9%) | 416 (97.2%) | 1.000 (reference) | 1.000 (reference) |
| GA | 17 (2.0%) | 10 (2.3%) | 1.185 (0.538–2.611) | 1.696 (0.641–4.485) |
| AA | 1 (0.1%) | 2 (0.5%) | 4.029 (0.364–44.559) | |
| AG + AA | 18 (2.1%) | 12 (2.8%) | 1.343 (0.641–2.814) | 2.039 (0.801–5.190) |
| rs1966265 | ||||
| AA | 221 (25.8%) | 107 (25.0%) | 1.000 (reference) | 1.000 (reference) |
| AG | 420 (49.1%) | 226 (52.8%) | 0.913 (0.653–1.275) | 0.808 (0.500–1.306) |
| GG | 215 (25.1%) | 95 (22.2%) | 1.111 (0.838–1.473) | 1.394 (0.945–2.056) |
| AG + GG | 635 (74.2%) | 321 (75.0%) | 1.044 (0.799–1.364) | 1.187 (0.818–1.723) |
CIs: Confidence intervals; OR: Odds ratio with their 95% confidence intervals were estimated by logistic regression models. AOR: Adjusted odds ratio with their 95% confidence intervals were estimated by multiple logistic regression models after controlling for age, gender, and tobacco consumption.