Figure 6.

All the cell types in the CNS release EVs of different size, origin, and composition. For clarity, both larger and smaller vesicles have been coloured the same colour as the producing cell. A few components of the vesicles are reported in the inserts with the relevant references [27,31,179,182,183,184,189,197,198,199,200,201]. Abbreviations: ApoD, apoprotein D; BBB, blood–brain barrier; CNP, 2′,3′-Cyclic Nucleotide 3′ Phosphodiesterase; EAAT, excitatory amino acid transporter; FGF, fibroblast growth factor; GS, glutamine synthetase; MAG, myelin-associated glycoprotein; MBP, myelin basic protein; MCT1, monocarboxylate transporter 1; MMPs, matrix metallopeptidases; MOG, myelin oligodendrocyte glycoprotein; MVB: multivescicular body; PLP, myelin proteolipid protein; PRP^C, cellular prion protein; VEGF, vascular endothelial growth factor.