Figure 6.

In vivo anti-tumor activity of novel combinations. (A) The mice carrying 8505C thyroid cancer cell xenografts were treated with either lenvatinib, KPT-330, KPT-9274 or a combination of lenvatinib with KPT-330/KPT-9274 and the effect of these treatments on tumor volume was assessed up to 35 days post-transplantation. (B) Photograph showing changes in the size of tumors harvested from different mice groups at the end of the experiment. (C) Body weight changes during the course of the treatment. (D) Gross tumor weight at the end of the treatment period. (E,F) Immunostaining for ki67 of the tissue sections of tumors harvested from untreated mice as well as from those receiving different treatments. Images were taken at 200× magnification. (G) RT-PCR analysis on RNA isolated from tumors showing comparative expression of Vimentin mRNA in various treatment groups. ** p < 0.01