Table 1.
Hypoxia-mediated gene-expression regulation in neuroblastoma.
| Cellular Processes | Genes | References | |
|---|---|---|---|
| Initiation | ↑ HIF-1α, HIF-2α, SNAIL-2, SOX10, CXCR4, PDGF1-α, FZD-6, TRKAIII | [21,22,23,25,26,31] | |
| Differentiation | ↑ IGF-2, NESP55, ID2, HES-1, TH, DDC, HIF-2α, OCT4, NOTCH1, c-Kit, Vimentin, dHAND | ↓ GAP-43, CHGA | [37,38,39,42,44] |
| Cell survival | ↑ HIF-1α, HIF-2α, VEGF, NEUROPILIN 1, ADRENOMEDULLIN, IGF-1, IGF-2, RHOA, BCL-2, Survivin, Methallothioneins, p53, MDM2 | [39,54,56,58,59,60,61,68] | |
| Metastasis | ↑ VEGF, TRIO, SERPINB9, ITGA7, HGFR, TGFβ1, IL1B, MMP2, TWIST1, SNAIL1, CDH1, HIF-1α | ↓ TIMP4, CDH1, CTNNB1, FN1 | [24,39,74,75,76,77,78,79,81] |
| Malignant phenotype | ↑ LCO4A1, ENO1, HK2, PGK1, MTFP1, HILPDA, VKORC1, TPI1, HIST1HIC | [49] | |
Arrow pointing downwards: decrease in expression. Arrow pointing upwards: increase in expression.