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Survival of mice in response to high- and low-dose Herpes Simplex Virus Type 2 (HSV-2) infection when treated with curcumin nanoparticles. Depo-treated mice (n = 5–10 per group) received either water, 0.5 mg vehicle-only nanoparticles or 0.5 mg curcumin in nanoparticles IVAG, 2 h prior to inoculation with HSV-2 at (A) high dose (104 PFU/mouse) or (B) low dose (103 PFU/mouse). Survival was monitored for 8–10 days post-infection and is displayed as % survival per day post-infection.
