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. 2020 Jan 4;21(1):337. doi: 10.3390/ijms21010337

Figure 6.

Figure 6

Survival of mice in response to high-dose HSV-2 infection after treatment with crude or solubilized curcumin. Depo-treated mice (n = 5–15 per group) received IVAG inoculation with either PBS or 1 mg of crude curcumin or 100 µg of curcumin in PVP-K30- or Soluplus®-based solid dispersion formulations and, after 6 h, were infected with 5 × 104 PFU/mouse of HSV-2 virus IVAG. Survival was monitored for 20 days post-infection and is displayed as % survival per day post-infection. Differences were statistically significant by the Mantel–Cox log-rank test: HSV-2 alone vs. crude curcumin: p < 0.0001, HSV-2 alone vs. Soluplus® curcumin: p = 0.0027, HSV-2 alone vs. PVP-K30: p = 0.0002, PVP vs. Soluplus®: p = 0.0308, Crude vs. Soluplus®: p = 0.0006, and Crude vs. PVP: p = 0.0457.