Table 2.
Scores of tissue inflammation following intravaginal delivery of curcumin-loaded nanoparticles prior to inoculation with CpG-ODN.
| Pre-Treatment | CpG-ODN | Mouse | Pathology Score | Average Score per Mouse (± S.D.) |
|---|---|---|---|---|
| Water | N | 1 | 0 | 0.33 (0.58) **,^ |
| 2 | 0 | |||
| 3 | 1 | |||
| Water | Y | 1 | 3 | 2.67 (0.58) * |
| 2 | 3 | |||
| 3 | 2 | |||
| Vehicle-Only Nanoparticles | Y | 1 | 1 | 1.67 (0.58) * |
| 2 | 2 | |||
| 3 | 2 | |||
| Curcumin Nanoparticles | Y | 1 | 0 | 0.50 (0.58) **,^ |
| 2 | 1 | |||
| 3 | 0 | |||
| 4 | 1 |
Statistical significance (Kruskal–Wallis test of one-way ANOVA with Dunn’s multiple comparisons test) and with alpha < 0.05 compared to: negative control *; CpG only positive control **; vehicle-only nanoparticles ^.