Table 4.

Cumulative pathology for mice pre-treated intravaginally with crude or solid dispersion formulations of curcumin and infected with HSV-2.

Pre-Treatment	Number of Mice	Mice with Pathology Score ≥3 by Day 6	Cumulative Pathology Score	Average Score per Mouse
PBS	5	5	182	36.4
Crude Curcumin	5	3	112	22.2
Curcumin in PVP-K30	5	0	60	12.0
Curcumin in Soluplus®	5	0	59	11.8

Pre-treatment was 6 h prior to HSV-2 infection. Pathology was monitored for 12 days in all curcumin treated groups and 8 days in PBS control group.