Nr4a1 interacts with LKB1 to maintain glucose and lipid homeostasis in T2DM rats. (A) Relative LKB1 mRNA expression in T2DM rats measured by RT-qPCR, n=3, data were analyzed by t test; (B) Levels of blood glucose indicators in T2DM rats measured by blood glucose meter, n=6; (C) Levels of blood lipid indicators in T2DM rats measured by blood lipid kit, n=6; (D) Representative images of WAT volume in T2DM rats detected by HE staining, n=3. Repetition=3. Data in panel B and C were analyzed by one-way ANOVA. * Compared with the T2DM group, p<0.05; # compared with the T2DM+Nr4a1 group, p<0.05. Nr4a1 – nuclear receptor subfamily 4 group A member 1; WAT – white adipose tissue; T2DM – type 2 diabetes mellitus; HE – hematoxylin and eosin; RT-qPCR – reverse transcription quantitative polymerase chain reaction; AST – aspartate transaminase; ALT – alanine transaminase; FBG – fasting blood glucose; PBG – postprandial blood glucose; TC – total cholesterol; TG – triglyceride; ANOVA – analysis of variance.