Table 1. Correlation between immunohistochemical variables and clinicopathologic features of ICC patients in the cohort (n = 322).

Characteristics	CD68+ TAMs			CD86+ TAMs			CD206+ TAMs
	Low	High	P#	Low	High	P#	Low	High	P#
Age, years
≤51	88	81	0.503	87	82	0.655	79	90	0.264
>51	73	80		74	79		82	71
Gender
Female	69	59	0.305	57	71	0.139	71	57	0.139
Male	92	102		104	90		90	104
Hepatitis history
No	104	94	0.303	94	104	0.303	100	98	0.909
Yes	57	67		67	57		61	63
CA199 (U/ml)
≤36	85	72	0.181	67	90	0.014	86	71	0.118
>36	76	89		94	71		75	90
Lymph node metastasis
No	135	131	0.659	124	142	0.012	143	123	0.005
Yes	26	30		37	19		18	38
Liver cirrhosis
No	121	115	0.529	107	129	0.008	126	110	0.058
Yes	40	46		54	32		35	51
Tumor size (cm)
≤5	75	70	0.654	75	70	0.654	80	65	0.117
>5	86	91		86	91		81	96
Tumor number
Single	121	123	0.897	120	124	0.697	123	121	0.897
Multiple	40	38		41	37		38	40
Vascular invasion
No	135	141	0.426	133	143	0.151	145	131	0.038
Yes	26	20		28	18		16	30
Tumor encapsulation
None	146	137	0.171	145	138	0.305	141	142	1.000
Complete	15	24		16	23		20	19
Tumor differentiation
I–II	127	122	0.595	122	127	0.595	127	122	0.595
III	34	39		39	34		34	39
TNM stage
I + II	129	119	0.233	116	132	0.046	137	111	0.001
III + IV	32	42		45	29		24	50

Notes:

ICC, intrahepatic cholangiocarcinoma; TNM, tumor-node-metastasis.

Bold values indicate P < 0.05.

^#The Pearson Chi square test was applied.