Table 2. Univariate and multivariate analysis of factors related to OS of ICC patients in the cohort (n = 322).
| OS | ||||
|---|---|---|---|---|
| Univariate | Multivariate | |||
| P | HR | 95% CI | p | |
| Age, years (>51 vs. ≤51) | 0.965 | NA | ||
| Gender (male vs. female) | 0.339 | NA | ||
| Hepatitis history (positive vs. negative) | 0.099 | NA | ||
| CA199, U/ml (>36 vs. ≤36) | <0.001 | 1.404 | [1.069–1.843] | 0.014 |
| Lymph node metastasis (yes vs. no) | <0.001 | 1.974 | [1.071–3.639] | 0.029 |
| Liver cirrhosis (yes vs. no) | 0.257 | NA | ||
| Tumor size (cm) (>5 vs. ≤5) | 0.002 | NS | ||
| Tumor multiplicity (multiple vs. single) | 0.003 | 1.523 | [1.121–2.069] | 0.007 |
| Tumor encapsulation (none vs. complete) | 0.134 | NA | ||
| Tumor differentiation (poor vs. well) | 0.581 | NA | ||
| Vascular invasion (yes vs. no) | 0.225 | NA | ||
| TNM stage (III + IV vs. I + II) | <0.001 | NS | ||
| CD86+/CD206+ TAMs predictive modela | <0.001 | 0.003 | ||
| II vs. I | 0.028 | 1.433 | [1.016–2.020] | 0.040 |
| III vs. I | 0.043 | NS | ||
| IV vs. I | <0.001 | 1.211 | [1.039–1.411] | 0.014 |
Notes:
ICC, intrahepatic cholangiocarcinoma; OS, overall survival; TNM, tumor-node-metastasis; HR, hazard ratio; CI, confidential interval; NA, not applicable; NS, not significant. Univariate analysis was performed by Kaplan–Meier method (log-rank test). Multivariate analysis was calculated using the Cox multivariate proportional hazard regression model with stepwise manner.
Bold values indicate P < 0.05.
a
Patients were divided into 4 groups based on their staining densities of CD86 and CD206 positive TAMs: group I, high expression of CD86 but low expression of CD206; group II, both low expressions; group III, both high expressions; group IV, low expression of CD86 but high expression of CD206.