Table 2.

Comparison of the Performance of Serum miRNAs and serum Exosomal miRNAs in Diagnosing the Patients with NSCLC at Early Stages

Marker	AUC	SE	95% CI	P Value
Serum miR-21-5p	0.754	0.0423	0.670 - 0.825	<0.0001
Serum miR-141-3p	0.748	0.0432	0.664 - 0.821	<0.0001
Serum miR-222-3p	0.779	0.0408	0.697 - 0.847	<0.0001
Serum miR-486-5p	0.697	0.0468	0.610 - 0.775	<0.0001
Combined serum miRNAs	0.871	0.0374	0.800 - 0.923	<0.0001
Exosomal miR-146a-5p	0.813	0.0421	0.735 - 0.877	<0.0001
Exosomal miR-486-5p	0.886	0.0304	0.817 - 0.935	<0.0001
Combined exosomal miRNAs	0.898	0.0301	0.832 - 0.945	<0.0001
Combined serum miRNAs + exosomal miR-146a-5p	0.944	0.0193	0.889 - 0.977	<0.0001
Combined serum miRNAs + exosomal miR-486-5p	0.957	0.0160	0.906 - 0.985	<0.0001
Combined serum miRNAs + exosomal miRNAs	0.960	0.0152	0.910 - 0.987	<0.0001

Notes: Combined serum miRNA=serum miR-21-5p+serum miR-141-3p+ serum miR-222-3p + serum miR-486-5p; Combined exosomal miRNA= exosomal miR-146a-5p+ exosomal miR-486-5p

Abbreviations: NSCLC, non-small-cell lung cancer; AUC, area under the curve; SE, standard error; CI, confidence interval.