Table 1:

Parameters for Cost-Effectiveness Model

Variable	Base Case	Citation	Range Tested	Distribution‡
Age	70	SEER12	55 – 85	Binomial
Five-year disease-free survival	0.61	Dziedzic21	0.25 – 0.8	Beta
Five-year overall survival	0.55	SEER12	0.3 – 0.6	Beta
Health utilities				Beta
Disease-free	0.79	Tramontano15	0.76 – 0.83
Disease-recurrence	0.76	Tramontano15	0.70 – 0.80
Benefit related to exercise*	0.05	Groessl13	0.01 – 0.10
Costs ($/patient/year)				Gamma
Exercise interventions**
LIFE physical activity	1,361 (1,855)	Groessl13	500 – 2,500
LIFE health education	413 (1,210)	Groessl13	250 – 1,000
Usual care	0 (203)	N/A†	N/A
Treatment of recurrent disease	95,363	Bradley19	80,000–120,000
Probability of increasing exercise				Beta
Physical activity/exercise	0.60	Gordon16	0.40 – 0.80
Health education	0.10	N/A†	0.10 – 0.20
Usual care	0	N/A†	0 – 0.10
Probability of dropout/lost to follow-up*	0.10	Speck17	0.10 – 0.20	Beta

^*Parameter values at one year.

^**Opportunity costs entered in parentheses.

^†Parameter assumed.

^‡Per standard recommendations for cost-effectiveness analysis models ⁴⁰.

LIFE = Lifestyle Interventions and Independence for Elders study; SEER = Surveillance, Epidemiology, and End Results program