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. Author manuscript; available in PMC: 2021 Jan 17.
Published in final edited form as: ChemMedChem. 2019 Dec 4;15(2):210–218. doi: 10.1002/cmdc.201900560

Scheme 1: General synthetic route and routes to compounds 2, 13 and 36.

Scheme 1:

Reagents and conditions: (a) PCl3, toluene, reflux, 16h; (b) CH3I, K2CO3, acetone, rt, 16h; (c) phenyl boronic acid, PdCl2(PPh3), K2CO3, THF, reflux, 48h; (d) SnCl2, HCl/EtOH, 70 °C, 12h.