Table 1.

Colistin MICs against AB 4106 and KP B9 in the presence of lead IMD-0354 analogues

Compounda	AB 4106 MIC (μg/mL) (fold reduction)	KP B9 MIC (μg/mL) (fold reduction)
IMD-0354	2 (1024)b	0.5 (1024)c
9	2 (1024)	0.25 (2048)
10	0.5 (4096)	0.5 (1024)
15	1 (2048)	0.25 (2048)
22	2 (1024)	0.25 (2048)
23	2 (1024)	0.25 (2048)
24	0.5 (4096)	0.5 (1024)
25	1 (2048)	0.25 (2048)
26	1 (2048)	0.25 (2048)
29	1 (2048)	0.5 (1024)
37	1 (2048)	0.25 (2048)
43	2 (1024)	0.125 (4096)
49	1 (2048)	0.25 (2048)
50	4 (512)	0.25 (2048)
51	1 (2048)	0.125 (4096)
52	1 (2048)	0.5 (1024)
55	1 (2048)	0.5 (1024)
56	1 (2048)	0.5 (1024)
60	1 (2048)	0.5 (1024)

^aAll compounds screened at 5 μM.

^bMIC of colistin alone is 2048 μg/mL.

^cMIC of colistin alone is 512 μg/mL.