Table 3.
CircRNAs related to colorectal cancer
| Circular RNA | Expression in CRC | Target | miRNA sponge | Model/Source | Type of cell line | Ref |
|---|---|---|---|---|---|---|
| has_circ_103809 | Down | FOXO4 | miR-532–3P | In vitro, Human/CRC tissues (n=30) | SW620, HCT116, COCA-2, HT29 | (Bian et al., 2018) |
| circITCH | Down | Wnt/β-catenin signaling pathway | miR-214 | In vitro, Human/CRC tissues (n=45) | HCT116, SW480 | (Huang, Guanli et al., 2015) |
| hsa_circ_0000523 | Down | Dkk1 | miR-31 | In vitro | COLO205, COLO320HSR, DLD-1, HCT-15, HCT-8, SW480, SW620, SW1116, HT-29, LoVo, NCM460, FHC, LS 174T, Caco-2 | (Jin et al., 2018) |
| circDDX17 (hsa_circ_0002211) | Down | - | - | Human/CRC tissues (n=60) | - | (Li, X.N. et al., 2018) |
| hsa_circ_0001649 | Down | - | - | In vitro, Human/CRC tissues (n=64), Serum (n=18) | HCT116 | (Ji, W. et al., 2018) |
| hsa_circ_0000711 | Down | - | - | In vitro, Human/CRC tissues (n=101) | HCT116, H-T29, COLO205 | (Li, Jinyun et al., 2018) |
| hsa_circ_0000567 | Down | - | - | Human/ In vitro/CRC tissues (n=102) | SW480, SW620, RKO, HCT116, CACO2 | (Wang, J. et al., 2018) |
| hsa_circ_0026344 | Down | - | miR-31, miR-21 | In vitro, Human/CRC tissues (n=32) | SW620, HCT116, HT29, SW480 | (Yuan, Yuan et al., 2018) |
| hsa_circ_104700 | Down | - | - | Human/CRC tissues (n=170) | - | (Zhang, Peili et al., 2017) |
| circITGA7 | Down | NF1 | miR-370–3p | Human/CRC tissues (n=69) | - | (Li, Xiaomin et al., 2018) |
| hsa_circ_0014717 | Down | p16 | - | In vitro, Human/CRC tissues (n=46) | HCT116, SW480, HT29 | (Wang, Feng et al., 2018) |
| hsa_circ_001988 | Down | - | - | Human/CRC tissues (n=62) | - | (Wang, Xuning et al., 2015) |
| hsa_circ_0003906 | Down | - | - | In vitro, Human/CRC tissues (n=122) | HCT8, SW480, LoVo, HCT116, HT29, SW620 | (Zhuo, Fan et al., 2017) |
| circACAP2 | Up | Tiam1 | miR-21–5p | In vitro, Human/CRC tissues (n=21) | SW480 | (He et al., 2018) |
| hsa_circ_001569 | Up | E2F5, FMNL2, BAG4 | miR-145 | In vitro, Human/CRC tissues (n=30) | SW480, HCT116 | (Shen, H. et al., 2015) |
| hsa_circ_0020397 | Up | TERT PD-L1 | miR-138 | In vitro | SW480, LoVo, SW620, HCT116 | (Zhang, X.l. et al., 2017) |
| hsa_circ_0071589 | Up | EZH2 | miR-600 | In vitro, Human/CRC tissues (n=40) | HCT116 | (Yong et al., 2018) |
| hsa_circ_0000069 | Up | - | - | In vitro, Human/CRC tissues (n=30) | HCT-116, HT-29, SW480, LoVo | (Guo, J.-n. et al., 2016) |
| hsa_circ_0007534 | Up | - | - | Human/CRC tissues (n=33) | - | (Zhang, R. et al., 2018) |
| hsa_circ_000984 | Up | CDK6 | miR-106b | In vitro, Human/CRC tissues (n=32) | HT29, W480, SW620 | (Xu, X.W. et al., 2017) |
| hsa_circ_0055625 | Up | ITGB8 | miR-106b-5p | Human/CRC tissues | - | (Zhang, J. et al., 2019) |
| circBANP | Up | p-Akt | - | In vitro, Human/CRC tissues (n=35) | HT29, HCT116 | (Zhu, Mingchen et al., 2017) |
| ciRS-7 | Up | EGFR/RAF1/MAPK pathway | miR-7 | In vitro, Human/CRC tissues (n=44) | HT29, HCT116 | (Tang et al., 2017) |
| circRNA_100290 | Up | FZD4 | miR-516b | In vitro, Human/CRC tissues (n=24) | HT29, HCT116, SW620, SW480 | (Fang et al., 2018) |
| hsa_circ_0136666 | Up | SH2B1 | miR-136 | In vitro | Cell line | (Jin et al., 2019) |
| circHIPK3 | Up | FAK, YY1, EGFR, IGF1R | miR-7 | In vitro, Human/CRC tissues (n=178) | HCT116, SW620, HT29, DLD1, SW480 | (Zeng, K. et al., 2018) |
| circCCDC66 | Up | - | - | In vitro, Human/CRC tissues (n=48) | HCT116, HT-29 | (Hsiao, K.-Y. et al., 2017) |