Table 6.

Role of circRNAs in hepatocellular carcinoma

circRNAs	Dysregulation	Target	Model	Type of cell line	Ref
Hsa_circ_0091579	Up		Human	-	(Zhang, C. et al., 2018)
Hsa_circ-101368	Up	HMGB1/RAGE signaling	Human, In vitro	HCCLM3	(Li, S. et al., 2018)
CircSETD3 (hsa_circRNA_0000567/hsa_circRNA_101436)	Down		Human, In vitro		(WHO, 2019)
Hsa_circRNA-104718	Up	miR-218–5p/TXNDC5 signaling pathway	Human, In vivo	SMMC-7721, HepG2, MHCC-LM3, and SK-Hep1, HEK293T	(Yu et al., 2019)
Hsa_circ_0003570	Down	alpha-fetoprotein	Human, In vitro	HepG2, SMMC-7721, MHCC97L, MHCC97H, and HCCLM3, L02	(Fu et al., 2018)
Hsa_circ_0068669	Down		Human, In vitro	HCC	(Yao et al., 2018)
Hsa_circ_0078602	Down		Human		(Kou et al., 2019)
Circ5379–6	Down		In vitro, In vivo	hepG2, 293T, Huh-7, SK-hep-1	(Zhang, N. et al., 2018)
CSMARCA5 (hsa_circ_0001445)	Down	TIMP3, Sponging miR-17–3p and miR-181b-5p	Human, In vitro, In vivo		(Yu, J. et al., 2018)
CircPTGR1	Up	miR449a-MET pathway	In vitro	HepG2, L-O2, SMCC-7721, HEP3B, HUH7, MHCC97-L (97 L), MHCC 97H (97H), HCC-LM3 (LM3)	(Wang, G. et al., 2019)
Hsa_circ_0079929	Down	PI3K/AKT/mTOR signaling pathway	Human, In vitro, In vivo	SK-Hep-1, SMMC-7721, 7702, LM-3, PRL-RF5	(Zheng et al., 2019)
CircHIPK3	Up	miR-124, AQP3	Human, In vitro	Huh7, MHCC-LM3, HepG2, SMMC-7721, PLC, L02, HEK293T	(Chen, G. et al., 2018)
Hsa_circ_0070269	Up	miR-182/NPTX1 axis	Human, In vitro	(Hep-3B, SMMC-7721, HepG2, PLC, Huh-7, LO2	(Su et al., 2019)
Hsa_circ_0028502, hsa_circ_0076251	Down		Human	-	(Jiang, Z. et al., 2019)
circular RNA PVT1	Up	miR-203/HOXD3 pathway	Human, In vitro	Huh7, Sk-hep1, SMMC-7721, HepG2, L-02	(Zhu, Y. et al., 2019)
Circ_0015756	Up	miR-7	Human, In vitro	WRL-68, MHCC97H, Bel-7402, Huh-7, Bel100	(Liu et al., 2019b)
hsa_circ_0085616	Up	β-catenin, p-ERK,p-AKT,	Human, In vitro	HepG2, MHCC-97L, MHCC-97H, Huh7, LM3	(Li et al., 2019)
Hsa_circ_0003998	Up	AFP,	Human, In vitro	HepG-2, HuH7, MHCC97H, PLC/PRF/5, L02	(Qiao et al., 2019)