(A, C, and E) Simulated mean residual lipid fraction (|Mz|/M0) as a function of T1 and B1,max, for conventional-OVS, ECLIPSE-OVS, and IR modules, respectively. (B, D, and F) Simulated residual water fraction (Mz/M0) as a function of T1 and B1 (represented as nutation angle for a 90° excitation pulse) for conventional-OVS, ECLIPSE-OVS, and IR modules, respectively. Water suppression was optimized to tolerate a 33.33% variation in B1 (60°−120° range in flip angle), and a T1 range spanning 500–3500 ms. The mean residual lipid fraction (|Mz|/M0) for the conventional-OVS module illustrated in (A) is calculated by averaging over the extracranial ROI associated with the ROI marked in yellow in Figure 1A.