Status epilepticus is a dynamic state with receptor trafficking potentially contributing to increased benzodiazepine resistance and further hyperexcitability over time.

Early initial benzodiazepine application of the recommended dose with quick escalation to second-line non-benzodiazepine anti-seizure medication is recommended.

Rational and early polytherapy by utilizing synergism between anti-seizure medications based on their pharmacokinetic and pharmacodynamic properties is a potential therapeutic target for future studies.