Table 1.
Attrition table and selection of cohorts
| ADHD | ASD | |
|---|---|---|
| At least 1 claim for ASD/ADHD at age at least 3 years | 5,978,601 | 612,856 |
| At least 2 claims for ASD/ADHD at age at least 3 years | 4,428,572 | 452,851 |
| Exclude individuals with claim for ASD (from ADHD cohort) and Rett’s syndrome (from ASD cohort) | 4,211,082 | 451,832 |
| Only include individuals enrolled for some time between age 3 and 18 (inclusive) and first claim for ASD/ADHD at age before 19 years | 2,240,854 | 326,246 |
| Exclude individuals with event of interest (stroke, myocardial infarction, serious cardiac arrhythmia) prior to first ASD/ADHD diagnosis claim | 2,240,774 | 326,221 |
| Total SCV events | 186 | 48 |
| Stroke | 102 | 25 |
| Myocardial infarction | 10 | 1 |
| Serious cardiac arrhythmia | 75 | 22 |
Composite event was the main event of interest, defined as the first of individual events
ADHD attention-deficit/hyperactivity disorder, ASD autism spectrum disorder, SCV events serious cardiovascular events