Table 2.
Sensitivity, Specificity and Predictive Value of CEA Marker
| CEA mRNA | CEA serum | CEA mRNA and/or CEA serum | CEA mRNA combined with CEA serum | |
|---|---|---|---|---|
| Sen % | 46.70% | 76.70% | 93.30% | 45.00% |
| Sen (95% CI) | 28.4 % to 65.7 % | 57.7% to 90.1% | 77.9% to 99.2% | 23.1% to 68.5% |
| Spe % | 93.30% | 90.00% | 83.30% | 96.70% |
| Spe (95% CI) | 77.9 % to 99.0 % | 73.5% to 97.9% | 65.3% to 94.4% | 82.8% to 99.9% |
| PPV | 87.50% | 88.50% | 84.80% | 90.00% |
| PPV (95% CI) | 61.6 % to 98.1 % | 69.8% to 97.5% | 68.1% to 94.9% | 55.5% to 99.7% |
| NPV | 63.60% | 79.40% | 92.60% | 72.50% |
| NPV (95% CI) | 47.8 % to 77.6 % | 62.1% to 91.3% | 75.7% to 99.1% | 56.1% to 85.4% |
Sen, Sensitivity; Spe, Specificity; PPV, Positive predictive value; NPV, Negative predictive value; DA, Diagnostic accuracy; 95% CI, 95% confidence interval; CEA or CEA serum marker, signifies positive if any of the two tested markers positive; CEA combined with CEA serum marker, signifies positive if both of the two tested markers positive.