Table 3.
Univariate and Multivariate Analyses Evaluating the Baseline Risk Factors that Affect Survival
| Overall survival |
||||
|---|---|---|---|---|
| Unadjusted HRa (95%CI) | p-value | Adjusted HR (95%CI) | p-value | |
| 25(OH)D levels stratified by age b | ||||
| Insufficient/sufficient (≥16 ng/ml) | Reference | Reference | ||
| Inadequate (<16 ng/ml) | 2.626 (1.344-5.130) | 0.005 | 2.474 (1.084-5.644) | 0.031 |
| 25(OH)D levels stratified by BMI c | ||||
| Insufficient/sufficient (≥16 ng/ml) | Reference | Reference | ||
| Inadequate (<16 ng/ml) | 2.541 (1.261-5.122) | 0.009 | 2.699 (1.161-6.272) | 0.021 |
| 25(OH)D levels stratified by Stagec | ||||
| Insufficient/sufficient (≥16 ng/ml) | Reference | Reference | ||
| Inadequate (<16 ng/ml) | 2.138 (1.086-4.207) | 0.028 | 2.429 (1.148-5.139) | 0.02 |
| 25(OH)D levels stratified by HER-2c | ||||
| Insufficient/sufficient (≥16 ng/ml) | Reference | Reference | ||
| Inadequate (<16 ng/ml) | 2.448 (1.188-5.045) | 0.015 | 2.499 (1.095-5.704) | 0.03 |
| 25(OH)D levels stratified by LN d | ||||
| Insufficient/sufficient (≥16 ng/ml) | Reference | Reference | ||
| Inadequate (<16 ng/ml) | 3.190 (1.557-6.534) | 0.002 | 2.493 (1.090-5.704) | 0.03 |
| 25(OH)D levels stratified by PR e | ||||
| Insufficient/sufficient (≥16 ng/ml) | Reference | Reference | ||
| Inadequate (<16 ng/ml) | 2.942 (1.494-5.794) | 0.002 | 2.559 (1.113-5.884) | 0.027 |
| 25(OH)D levels stratified by P53 e | ||||
| Insufficient/sufficient (≥16 ng/ml) | Reference | Reference | ||
| Inadequate (<16 ng/ml) | 2.972 (1.469-6.014) | 0.002 | 2.518 (1.098-5.773) | 0.029 |
| 25(OH)D levels stratified by ER f | ||||
| Insufficient/sufficient (≥16 ng/ml) | Reference | Reference | ||
| Inadequate (<16 ng/ml) | 3.115 (1.581-6.141) | 0.001 | 2.966 (1.399-6.286) | 0.005 |
| 25(OH)D levels stratified by Ki-67 g | ||||
| Insufficient/sufficient (≥16 ng/ml) | Reference | Reference | ||
| Inadequate (<16 ng/ml) | 2.325 (1.075-5.031) | 0.032 | 2.462 (1.050-5.773) | 0.038 |
a, Hazard ratio; b, Adjusted for LN, ER, and HER-2; c, Adjusted for age, LN, and ER; d, Adjusted for age, ER, and HER-2; e, Adjusted for age, LN, ER, and HER-2; f, Adjusted for age, LN, and HER-2; g, Adjusted for LN and p53”