Table 2.
Multivariable Analysis Potential Prognostic Fctors, with OS as the Outcome
| Variables | HR | 95% CI | P value |
|---|---|---|---|
| Age below/above the median (≤ 67 vs. ≥ 68 years) | 0.9 | 0.42-1.96 | n.s. |
| Gender (male vs. female) | 1.74 | 0.69-4.40 | n.s. |
| Changes in ECOG-PS (stable vs. deterioration) | 1.58 | 0.68-3.66 | n.s. |
| CCI (≤ 7 vs. ≥ 8) | 1.04 | 0.44-2.44 | n.s. |
| Disease control (CR, PR and SD vs. PD) | 1.12 | 0.39-3.20 | n.s. |
| SMI inclination (steep vs. gentle) | 2.38 | 1.05-5.38 | 0.037 |
| Hb at starting GD below/above (≥ 10 vs. <10 g/dl) | 2.23 | 1.00-5.00 | 0.049 |
| Changes in body weight below/above the median (≥ -1.35 vs. < -1.35 kg) | 1.16 | 0.51-2.63 | n.s. |
| Liver metastasis (absence vs. presence) | 0.96 | 0.15-6.29 | n.s. |
| Time from starting 1st line chemotherapy below/above the median (< 202 vs. ≥ 202 days) | 1 | 1.00-1.00 | n.s. |
OS, Overall survival; HR, Hazard ratio; CI, Confidence interval; ECOG-PS, Eastern Cooperative Oncology Group Performance Status; CR, Complete response; PR, Partial response; SD, Stable disease; PD, Progressive disease; CCI, Charlson comorbidity index; SMI, Skeletal mass index; GD, Gemcitabine and docetaxel