Table 4.
Association between Haematological Toxicities and Genetic Polymorphisms (DPYD*9A, DPYD*6 and GSTP1 ile105val)
| S.no | Model | Genotype | Freq | Observed toxicity across genotypes |
|||
|---|---|---|---|---|---|---|---|
| Anemia | Thrombocytopenia | Neutropenia | |||||
| 1 | DPYD*9A | AA | 100 | 45 | 28 | 20 | |
| AG | 35 | 12 | 17 | 6 | |||
| GG | 10 | 7 | 5 | 5 | |||
| Dominant model | AA (ref) AG+GG | 100 35+10 |
P-value Odds (CI) |
0.8 0.9 (0.4-1.8) |
0.01* 2.4 (1.18-5.1) |
0.5 1.24 (0.5-2.9) |
|
| 2 | DPYD*6 | CC | 122 | 54 | 41 | 24 | |
| CT | 18 | 8 | 7 | 6 | |||
| TT | 5 | 2 | 2 | 1 | |||
| Dominant model | CC(ref) CT+TT | 122 18+5 |
P-value Odds (CI) |
0.8 1.9 (0.4-2.6) |
0.6 1.2 (0.5-3.1) |
0.2 1.7 (0.6-1.7) |
|
| 3 | GSTP1 ile105val | AA | 70 | 28 | 18 | 14 | |
| AG | 57 | 23 | 22 | 10 | |||
| GG | 18 | 8 | 10 | 7 | |||
| Dominant model | AA (ref) AG+GG |
70 57+18 |
P-value Odds (CI) |
0.8 0.9 (0.4-1.8) |
0.04 2 (1.1-4.1) |
0.6 1.2 (0.5-2.6) |
|
ref, Reference; *, Significant; The frequency of wild type allele (high frequency allele) was taken as reference for calculating the odds ratio in dominant model of genotyping analysis.