Table 5.
Association between Non-Haematological Toxicities and Genetic Variants (DPYD*9A, DPYD*6 and GSTP1 ile105val)
| S.no | Model | Genotype | Freq | Observed toxicity across genotypes |
||||
|---|---|---|---|---|---|---|---|---|
| Vomiting | Diarrhoea | HFS | PN | |||||
| 1 | DPYD*9A | AA | 100 | 35 | 18 | 37 | 32 | |
| AG | 35 | 17 | 8 | 18 | 10 | |||
| GG | 10 | 6 | 7 | 8 | 4 | |||
| Dominant model | AA (ref) AG+GG |
100 35+10 |
P value Odds (CI) | 0.06 1 (0.9-4) |
0.04 * 2.7 (1.8-4) |
0.02* 2.3 (1.8-4( |
0.9 09 (0.4-2) |
|
| 2 | DPYD*6 | CC | 122 | 49 | 25 | 54 | 38 | |
| CT | 18 | 9 | 6 | 7 | 5 | |||
| TT | 5 | 0 | 2 | 1 | 3 | |||
| Dominant model | CC (ref) CT+TT |
122 18+5 |
P value Odds (CI) | 0.9 1 (0.4-2) |
0.1 1.8 (0.7-2) |
0.3 0.6 (0.2-1) |
0.7 1.1 (0.4-2) |
|
| 3 | GSTP1 ile105val | AA | 70 | 28 | 15 | 32 | 21 | |
| AG | 57 | 18 | 10 | 21 | 13 | |||
| GG | 18 | 12 | 8 | 10 | 12 | |||
| Dominant model | AA (ref) AG+GG | 70 57+18 |
P value Odds (CI) | 0.8 1 (0.4-2) |
0.9 1 (0.4-2) |
0.2 1 (0.3-1) |
0.7 1.2 (0.5-2) |
|
ref, Reference; *, Significant; The frequency of wild type allele (high frequency allele) was taken as reference for calculating the odds ratio in dominant model of genotyping analysis.