Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Dec 19;25(1):15. doi: 10.3390/molecules25010015

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Effects of protopine on inflammatory response in mice with LPS-induced AKI (n = 8 mice per group). (A) Effects of protopine on inflammation accumulation in mice with LPS-induced AKI detected by small animal imaging. (B–E) Effects of protopine on inflammatory cytokines in mice with LPS-induced AKI. (F,G) Effects of protopine on TLR4 signaling pathway in mice with LPS-induced AKI. * p < 0.05, ** p < 0.01 compared with the LPS group. (CBA: cytometric bead array; LPRO: low-dose protopine; MPRO: medium-dose protopine; HPRO: high-dose protopine; LPS: lipopolysaccharide; AKI: acute kidney injury; IL-2: interleukin-2; IFN-γ: interferon-γ; IL-10: interleukin-10; TLR4: toll-like receptor 4; NLRP3: nod receptor heat protein domain associated protein 3; IL-1β: interleukin-1β; IL1R1: interleukin-1 receptor 1; GSDMD: gasdermin; MyD88: myeloiddifferentiationfactor88).