Table 2.
Analgesic activity of the compounds using the writhing test.
| Compound | Writhing Number in 20 min (Mean ± SEM) |
Analgesic Activity (% protection) |
|---|---|---|
| Control | 40 ± 0.5 | 0 |
| Diclofenac | 25 ± 1.2 a | 51 ± 1.15 a |
| 4a | 58 ± 1.5 a,b | 18 ± 1.20 |
| 4b | 56 ± 1.2 a,b | 19 ± 1.30 |
| 5a | 54 ± 1.6 a,b | 21 ± 2.10 |
| 5b | 52 ± 1.4 a,b | 23 ± 0.70 |
| 6a | 50 ± 1.6 a,b | 25 ± 0.50 |
| 6b | 49 ± 1.2 a,b | 26 ± 0.80 |
| 7a | 42 ± 1.8 a,b | 33 ± 1.70 |
| 7b | 40 ± 1.5 a,b | 35 ± 1.14 |
| 8a | 48 ± 1.9 a,b | 27 ± 0.60 |
| 8b | 47 ± 2.2 a,b | 28 ± 0.95 |
| 9a | 45 ± 2.4 a,b | 30 ± 1.05 |
| 9b | 44 ± 2.5 a,b | 32 ± 1.2 |
| 10a | 25 ± 1.3 a | 50 ± 1.6 a |
| 10b | 27 ± 1.1 a | 48 ± 1.5 a |
| 10c | 24 ± 1.5 a | 51 ± 1.4 a |
| 10d | 26 ± 1.2 a | 49 ± 1.1 a |
| 11a | 39 ± 2.1 a | 36 ± 0.75 a |
| 11b | 37 ± 2.3 a | 38 ± 0.80 a |
| 12a | 35 ± 1.2 a | 40 ± 1.50 a |
| 12b | 34 ± 1.7 a | 41 ± 1.10 a |
| 13a | 33 ± 1.9 a | 42 ± 1.90 a |
| 13b | 29 ± 1.5 a | 46 ± 1.6 a |
| 13c | 31 ± 1.1 a | 44 ± 0.85 a |
| 13d | 32 ± 1.4 a | 43 ± 1.90 a |
| 13e | 28 ± 1.3 a | 47 ± 1.7 a |
| 13f | 30 ± 1.8 a | 45 ± 0.95 a |
Values are expressed as mean ± SEM (n = 5). Data were analyzed using one-way ANOVA followed by a Bonferroni post hoc test. A p-value was considered significant if it was less than 0.05 compared to control; (a) Significantly different from the control group; (b) Significantly different from the diclofenac group.