Table 1.

ANOVA analysis of Box-Behnken test.

Source	Sum of Square	Degree of Freedom	Mean Square	F Value	p-Value	Significant
Model	482.13	9	53.57	117.59	<0.0001	**
A	77.5	1	77.50	170.12	<0.0001	**
B	22.71	1	22.71	49.86	0.0002	**
C	40.77	1	40.77	89.49	<0.0001	**
AB	0.027	1	0.027	0.06	0.8139
AC	15.17	1	15.17	33.3	0.0007	**
BC	3.55	1	3.55	7.8	0.0268	*
A2	245.98	1	245.98	539.93	<0.0001	**
B2	60.74	1	60.74	133.34	<0.0001	**
C2	6.16 × 10−3	1	6.16 × 10−3	0.014	0.9107
Residual	3.19	7	0.46
Lack of fit	0.28	3	0.093	0.13	0.9382
Error	2.91	4	0.73			R2 = 0.993
Total	485.32	16				Radj2 = 0.985

Note: ** in the table indicate significant difference at 0.01 level; * indicate significant difference at 0.05 level.