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. 2020 Jan 3;25(1):207. doi: 10.3390/molecules25010207

Table 1.

Cytotoxic activity of isoflavones isolated from Millettia ferruginea spp. ferruginea in human ovarian cancer cells.

graphic file with name molecules-25-00207-i001.jpg

Compound No Name IC50 a
A2780 SKOV3
1 6,7-dimethoxy-3′,4′-methylenedioxy-8-
(3,3-dimethylallyl)isoflavone (DMI)
0.45 ± 0.06 μM
(0.18 ± 0.02 μg/mL)
> 100 μM
(> 39.41 μg/mL)
2 Ferrugone 0.51 ± 0.06 μM
(0.21 ± 0.02 μg/mL)
36.78 ± 5.26 μM
(15.01 ± 2.15 μg/mL)
3 Prebarbigerone 32.06 ± 8.31 μM
(13.16 ± 3.41 μg/mL)
> 100 μM
(> 41.05 μg/mL)
- Cisplatin b 14.14 ± 0.59 μM
(4.24 ± 0.18 μg/mL)
36.64 ± 0.96 μM
(10.99 ± 0.29 μg/mL)

a IC50 values are defined as the concentration that results in a 50% decrease in the number of cells compared with that of the control cultures. b Cisplatin was used as a positive control.