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. 2019 Dec 24;25(1):77. doi: 10.3390/molecules25010077

Figure 1.

Figure 1

The measurement of competition of chalcone-donepezil hybrids 15a–15f and 16a–16f against 3H-PIB binding to Aβ fibrils and ADPBC at 10 μM. BTA-1 (2-(4′-methylaminophenyl)benzothiazole) was used as a positive control. F40 = Aβ(1–40) fibrils; F42 = Aβ(1–42) fibrils; ADPBC = PIB binding site located in the AD brain. Due to solubility-micellarization concerns that interferes with 3H-PIB binding measurements, compounds were not tested at concentrations greater than 10 μM. These experiments were performed in duplicate (n = 1 independent experiment). The error bars represent standard deviations (SDEV).