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The titration of chalcone-donepezil hybrids 15a–15e and 16a–16e against 3H-PIB binding to F42 (Aβ(1–42) fibrils) (A,B), ADPBC (PIB binding site located in the AD brain) (C,D), and F40 (Aβ(1–40) fibrils) (E,F). BTA-1 (2-(4′-methylaminophenyl)benzothiazole) was used as a positive control. The experiments with F42 and ADPBC were performed in duplicate (n = 1 independent experiment). The error bars represent standard deviations (SDEV).
