Figure 3.

The measurement of biotinyl-Aβ_(1–42) (bioAβ₄₂) oligomer assembly inhibition of compounds 3 and 15a–15f (A), and compounds 6 and 16a–16f (B). The experiments were performed over a concentration range of 1.56 to 50 μM. Donepezil and Tween 20 (assembly inhibition) were used as controls. For Tween 20, the concentration range used was 0.03–10 μM. The absorbance of the enzymatic readout of oligomer content was determined at 450 nm with a BioTek HT Synergy plate reader. These experiments were performed in duplicate (n = 1 independent experiment). The error bars represent standard deviations (SDEV).