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. Author manuscript; available in PMC: 2020 Jan 26.
Published in final edited form as: Science. 2018 Sep 28;361(6409):1363–1369. doi: 10.1126/science.aar8238

Fig. 4. Proposed Mechanism and Application.

Fig. 4.

A. Mechanistic hypothesis for interrupted carbonyl-olefin metathesis reactions. B. Investigation of mechanistic probe molecules. C. Synthesis of intermediates to access known and new Ledipasvir analogues.