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. Author manuscript; available in PMC: 2020 Jul 20.
Published in final edited form as: Nat Immunol. 2020 Jan 20;21(2):178–185. doi: 10.1038/s41590-019-0578-8

Figure 8. Transfer of the MC.7.G5 T cell receptor redirects patient T cells to recognise autologous melanoma.

Figure 8

(a) Metastatic melanoma patient (MM909.11 and MM909.24) derived T cells transduced with the T cell receptor of MC.7.G5 recognised autologous and non-autologous melanomas. Surface CD107a and intracellular TNF after 4h. Performed twice with similar results. (b) T cells from patient MM909.11 transduced with MC.7.G5 TCR killed autologous and non-autologous melanomas, but not healthy cells. Flow-based killing assay for 36h at a T cell to target cell ratio of 5:1. Bars depict the mean.